_uid domain testcd meddra_code meddra_soc ctcae_term programmatical grade_1___ grade_2___ grade_3___ grade_4___ grade_5___ definition navigational_note ctcae_v5_0_change
2 LB HGB 10002272 Blood and lymphatic system disorders Anemia Yes - symptoms Hemoglobin (Hgb) Hgb <10.0 - 8.0 g/dL; <6.2 - 4.9 mmol/L; <100 - 80g/L Hgb <8.0 g/dL; <4.9 mmol/L; <80 g/L; transfusion indicated Life-threatening consequences; urgent intervention indicated Death A disorder characterized by a reduction in the amount of hemoglobin in 100 ml of blood. Signs and symptoms of anemia may include pallor of the skin and mucous membranes, shortness of breath, palpitations of the heart, soft systolic murmurs, lethargy, and fatigability. Clarification: Definition
3 LB EOS 10014950 Blood and lymphatic system disorders Eosinophilia Yes >ULN and >Baseline - Steroids initiated - - A disorder characterized by laboratory test results that indicate an increased number of eosinophils in the blood. Addition: Term
4 LB HGBMET 10027506 Blood and lymphatic system disorders Methemoglobinemia Yes - >ULN Requiring urgent intervention Life-threatening consequences Death A disorder characterized by laboratory test results that indicate increased methemoglobin in the blood. Addition: Term
5 10019245 Ear and labyrinth disorders Hearing impaired Yes Adults enrolled on a Monitoring Program (on a 1, 2, 4, 3, 6, and 8 kHz audiogram): Threshold shift of 15 - 25 dB averaged at 2 contiguous test frequencies in at least one ear; Adults not enrolled on a Monitoring Program: Subjective change in hearing in the absence of documented hearing loss; Pediatric (on a 1, 2, 3, 4, 6, and 8 kHz audiogram): Threshold shift >20 dB hearing loss (HL) (i.e., 25 dB HL or greater); sensorineural hearing loss (SNHL) above 4 kHz (i.e., 6 or 8 kHz) in at least one ear Adults enrolled on a Monitoring Program (on a 1, 2, 3, 4, 6, and 8 kHz audiogram): Threshold shift of >25 dB averaged at 2 contiguous test frequencies in at least one ear; Adults not enrolled on a Monitoring Program: Hearing loss with hearing aid or intervention not indicated; limiting instrumental ADL; Pediatric (on a 1, 2, 3, 4, 6, and 8 kHz audiogram): Threshold shift >20 dB at 4 kHz in at least one ear Adults enrolled on a Monitoring Program (on a 1, 2, 3, 4, 6, and 8 kHz audiogram): Threshold shift of >25 dB averaged at 3 contiguous test frequencies in at least one ear; therapeutic intervention indicated; Adults not enrolled on a Monitoring Program: Hearing loss with hearing aid or intervention indicated; limiting self care ADL; Pediatric (on a 1, 2, 3, 4, 6, and 8 kHz audiogram): Hearing loss sufficient to indicate therapeutic intervention, including hearing aids; threshold shift >20 dB at 2 to < 4 kHz in at least one ear Adults: Decrease in hearing to profound bilateral loss (absolute threshold >80 dB HL at 2 kHz and above); nonservicable hearing Pediatric: Audiologic indication for cochlear implant; > 40 dB HL (i.e., 45 dB HL or more); SNHL at 2 kHz and above - A disorder characterized by partial or complete loss of the ability to detect or understand sounds resulting from damage to ear structures. Clarification: Grade 1, 2, 3, 4
6 VS TEMP 10016558 General disorders and administration site conditions Fever Yes 38.0 - 39.0 degrees C (100.4 - 102.2 degrees F) >39.0 - 40.0 degrees C (102.3 - 104.0 degrees F) >40.0 degrees C (>104.0 degrees F) for <=24 hrs >40.0 degrees C (>104.0 degrees F) for >24 hrs Death A disorder characterized by elevation of the body's temperature above the upper limit of normal.
7 VS TEMP 10021113 General disorders and administration site conditions Hypothermia Yes - 35 - >32 degrees C; 95 - >89.6 degrees F 32 - >28 degrees C; 89.6 - >82.4 degrees F <=28 degrees C; 82.4 degrees F; life-threatening consequences (e.g., coma, hypotension, pulmonary edema, acidemia, ventricular fibrillation) Death A disorder characterized by an abnormally low body temperature. Treatment is required when the body temperature is 35C (95F) or below.
8 LB APTT 10000636 Investigations Activated partial thromboplastin time prolonged Yes >ULN - 1.5 x ULN >1.5 - 2.5 x ULN >2.5 x ULN; bleeding - - A finding based on laboratory test results in which the partial thromboplastin time is found to be greater than the control value. As a possible indicator of coagulopathy, a prolonged partial thromboplastin time (PTT) may occur in a variety of diseases and disorders, both primary and related to treatment. Clarification: Grade 3, Definition
9 LB ALT 10001551 Investigations Alanine aminotransferase increased Yes >ULN - 3.0 x ULN if baseline was normal; 1.5 - 3.0 x baseline if baseline was abnormal >3.0 - 5.0 x ULN if baseline was normal; >3.0 - 5.0 x baseline if baseline was abnormal >5.0 - 20.0 x ULN if baseline was normal; >5.0 - 20.0 x baseline if baseline was abnormal >20.0 x ULN if baseline was normal; >20.0 x baseline if baseline was abnormal - A finding based on laboratory test results that indicate an increase in the level of alanine aminotransferase (ALT or SGPT) in the blood specimen. Also consider Hepatobiliary disorders: Hepatic failure Addition: Navigational note; Clarification: Grade 1, 2, 3, 4
10 LB ALP 10001675 Investigations Alkaline phosphatase increased Yes >ULN - 2.5 x ULN if baseline was normal; 2.0 - 2.5 x baseline if baseline was abnormal >2.5 - 5.0 x ULN if baseline was normal; >2.5 - 5.0 x baseline if baseline was abnormal >5.0 - 20.0 x ULN if baseline was normal; >5.0 - 20.0 x baseline if baseline was abnormal >20.0 x ULN if baseline was normal; >20.0 x baseline if baseline was abnormal - A finding based on laboratory test results that indicate an increase in the level of alkaline phosphatase in a blood specimen. Clarification: Grade 1, 2, 3, 4
11 LB ASP 10003481 Investigations Aspartate aminotransferase increased Yes >ULN - 3.0 x ULN if baseline was normal; 1.5 - 3.0 x baseline if baseline was abnormal >3.0 - 5.0 x ULN if baseline was normal; >3.0 - 5.0 x baseline if baseline was abnormal >5.0 - 20.0 x ULN if baseline was normal; >5.0 - 20.0 x baseline if baseline was abnormal >20.0 x ULN if baseline was normal; >20.0 x baseline if baseline was abnormal - A finding based on laboratory test results that indicate an increase in the level of aspartate aminotransferase (AST or SGOT) in a blood specimen. Also consider Hepatobiliary disorders: Hepatic failure Addition: Navigational note; Clarification: Grade 1, 2, 3, 4
12 LB BICARB 10005359 Investigations Blood bicarbonate decreased Yes - symptoms - - - - A finding based on laboratory test results that indicate a decrease in levels of bicarbonate in a venous blood specimen. Also consider Metabolism and nutrition disorders: Acidosis or Alkalosis Addition: Term, Navigational note
13 LB BILI 10005364 Investigations Blood bilirubin increased Yes >ULN - 1.5 x ULN if baseline was normal; > 1.0 - 1.5 x baseline if baseline was abnormal >1.5 - 3.0 x ULN if baseline was normal; >1.5 - 3.0 x baseline if baseline was abnormal >3.0 - 10.0 x ULN if baseline was normal; >3.0 - 10.0 x baseline if baseline was abnormal >10.0 x ULN if baseline was normal; >10.0 x baseline if baseline was abnormal - A finding based on laboratory test results that indicate an abnormally high level of bilirubin in the blood. Excess bilirubin is associated with jaundice. Also consider Hepatobiliary disorders: Hepatic failure Addition: Navigational note; Clarification: Grade 1, 2, 3, 4
14 LB LDH 10005630 Investigations Blood lactate dehydrogenase increased Yes >ULN - - - - A finding based on laboratory test results that indicate increased levels of lactate dehydrogenase in the blood specimen. Addition: Term
15 LB CMONOX 10065906 Investigations Carbon monoxide diffusing capacity decreased Yes - symptoms 3 - 5 units below LLN; for follow-up, a decrease of 3 - 5 units (ml/min/mm Hg) below the baseline value; asymptomatic and intervention not indicated 6 - 8 units below LLN; for follow-up, an asymptomatic decrease of >5 - 8 units (ml/min/mm Hg) below the baseline value; symptomatic and intervention not indicated Asymptomatic decrease of >8 units drop; >5 units drop along with the presence of pulmonary symptoms (e.g., >Grade 2 hypoxia or >Grade 2 dyspnea); intervention indicated - - A finding based on lung function test results that indicate a decrease in the lung capacity to absorb carbon monoxide. Also consider Respiratory, thoracic and mediastinal disorders: Respiratory failure or Dyspnea Addition: Navigational note; Clarification: Grade 1, 2, 3
16 LB CD4 10007839 Investigations CD4 lymphocytes decreased Yes <500 - 200/mm3; <0.5 - 0.2 x 10e9 /L <200 - 50/mm3; <0.2 x 0.05 - 10e9 /L <50/mm3; <0.05 x 10e9 /L - A finding based on laboratory test results that indicate an decrease in levels of CD4 lymphocytes in a blood specimen.
17 LB CHOL 10008661 Investigations Cholesterol high Yes >ULN - 300 mg/dL; >ULN - 7.75 mmol/L >300 - 400 mg/dL; >7.75 - 10.34 mmol/L >400 - 500 mg/dL; >10.34 - 12.92 mmol/L >500 mg/dL; >12.92 mmol/L - A finding based on laboratory test results that indicate higher than normal levels of cholesterol in a blood specimen.
18 10011268 Investigations CPK increased Yes >ULN - 2.5 x ULN >2.5 x ULN - 5 x ULN >5 x ULN - 10 x ULN >10 x ULN - A finding based on laboratory test results that indicate an increase in levels of creatine phosphokinase in a blood specimen. Also consider Cardiac disorders: Heart failure or Cardiac disorders: Myocardial infarction. Report Cardiac disorders: Heart failure or Cardiac disorders: Myocardial infarction if same grade event. Addition: Navigational note
19 LB CREAT 10011368 Investigations Creatinine increased Yes >ULN - 1.5 x ULN >1.5 - 3.0 x baseline; >1.5 - 3.0 x ULN >3.0 x baseline; >3.0 - 6.0 x ULN >6.0 x ULN - A finding based on laboratory test results that indicate increased levels of creatinine in a biological specimen. Also consider Renal and urinary disorders: Acute kidney injury Addition: Navigational note; Clarification: Grade 1, 3
20 10050528 Investigations Ejection fraction decreased Yes - Resting ejection fraction (EF) 50 - 40%; 10 - 19% drop from baseline Resting ejection fraction (EF) 39 - 20%; >=20% drop from baseline Resting ejection fraction (EF) <20% - The percentage computed when the amount of blood ejected during a ventricular contraction of the heart is compared to the amount that was present prior to the contraction. Also consider Cardiac disorders: Left ventricular systolic dysfunction. Report Cardiac disorders: Left ventricular systolic dysfunction if same grade event. Addition: Navigational note; Clarification: Grade 3
21 EG QTC 10014383 Investigations Electrocardiogram QT corrected interval prolonged Yes Average QTc 450 - 480 ms Average QTc 481 - 500 ms Average QTc >= 501 ms; >60 ms change from baseline Torsade de pointes; polymorphic ventricular tachycardia; signs/symptoms of serious arrhythmia - A finding of a cardiac dysrhythmia characterized by an abnormally long corrected QT interval. Clarification: Grade 1, 2, 3, 4
22 LB FIBRINO 10016596 Investigations Fibrinogen decreased Yes <1.0 - 0.75 x LLN; if abnormal, <25% decrease from baseline <0.75 - 0.5 x LLN; if abnormal, 25 - <50% decrease from baseline <0.5 - 0.25 x LLN; if abnormal, 50 - <75% decrease from baseline <0.25 x LLN; if abnormal, 75% decrease from baseline; absolute value <50 mg/dL - A finding based on laboratory test results that indicate an decrease in levels of fibrinogen in a blood specimen. Clarification: Grade 1, 2, 3, 4
23 10016987 Investigations Forced expiratory volume decreased Yes FEV1% (percentages of observed FEV1 and FVC related to their respective predicted values) 99 - 70% predicted FEV1 60 - 69% 50 - 59% <= 49% - A finding based on test results that indicate a relative decrease in the fraction of the forced vital capacity that is exhaled in a specific number of seconds. Also consider Respiratory, thoracic and mediastinal disorders: Respiratory failure or Dyspnea Addition: Navigational note
24 LB GGT 10056910 Investigations GGT increased Yes >ULN - 2.5 x ULN if baseline was normal; 2.0 - 2.5 x baseline if baseline was abnormal >2.5 - 5.0 x ULN if baseline was normal; >2.5 - 5.0 x baseline if baseline was abnormal >5.0 - 20.0 x ULN if baseline was normal; >5.0 - 20.0 x baseline if baseline was abnormal >20.0 x ULN if baseline was normal; >20.0 x baseline if baseline was abnormal - A finding based on laboratory test results that indicate higher than normal levels of the enzyme gamma-glutamyltransferase in the blood specimen. GGT (gamma-glutamyltransferase ) catalyzes the transfer of a gamma glutamyl group from a gamma glutamyl peptide to another peptide, amino acids or water. Clarification: Grade 1, 2, 3, 4
25 LB HAPTOG 10019150 Investigations Haptoglobin decreased Yes - - - - A finding based on laboratory test results that indicate an decrease in levels of haptoglobin in a blood specimen.
26 LB HGB 10055599 Investigations Hemoglobin increased Yes Increase in >0 - 2 g/dL Increase in >2 - 4 g/dL Increase in >4 g/dL - - A finding based on laboratory test results that indicate increased levels of hemoglobin above normal. Clarification: Grade 1, 2, 3, Definition
27 LB INR 10022402 Investigations INR increased Yes >1.2 - 1.5; >1 - 1.5 x baseline if on anticoagulation; monitoring only indicated >1.5 - 2.5; >1.5 - 2.5 x baseline if on anticoagulation; dose adjustment indicated >2.5; >2.5 x baseline if on anticoagulation; bleeding - - A finding based on laboratory test results that indicate an increase in the ratio of the patient's prothrombin time to a control sample in the blood. Clarification: Grade 1, 2, 3
28 LB LIPASE 10024574 Investigations Lipase increased Yes >ULN - 1.5 x ULN >1.5 - 2.0 x ULN; >2.0 - 5.0 x ULN and asymptomatic >2.0 - 5.0 x ULN with signs or symptoms; >5.0 x ULN and asymptomatic >5.0 x ULN and with signs or symptoms - A finding based on laboratory test results that indicate an increase in the level of lipase in a biological specimen. Clarification: Grade 2, 3, 4
29 LB LYMPH 10025256 Investigations Lymphocyte count decreased Yes <800 - 500/mm3; <0.8 - 0.5 x 10e9 /L <500 - 200/mm3; <0.5 - 0.2 x 10e9 /L <200/mm3; <0.2 x 10e9 /L - A finding based on laboratory test results that indicate a decrease in number of lymphocytes in a blood specimen.
30 LB LYMPH 10025258 Investigations Lymphocyte count increased Yes - >4000/mm3 - 20,000/mm3 >20,000/mm3 - - A finding based on laboratory test results that indicate an abnormal increase in the number of lymphocytes in the blood, effusions or bone marrow.
31 LB NEUT 10029366 Investigations Neutrophil count decreased Yes <1500 - 1000/mm3; <1.5 - 1.0 x 10e9 /L <1000 - 500/mm3; <1.0 - 0.5 x 10e9 /L <500/mm3; <0.5 x 10e9 /L - A finding based on laboratory test results that indicate a decrease in number of neutrophils in a blood specimen.
32 10062646 Investigations Pancreatic enzymes decreased Yes Increase in stool frequency, bulk, or odor; steatorrhea Sequelae of absorption deficiency - - A finding based on laboratory test results that indicate an decrease in levels of pancreatic enzymes in a biological specimen.
33 LB PLAT 10035528 Investigations Platelet count decreased Yes <75,000 - 50,000/mm3; <75.0 - 50.0 x 10e9 /L <50,000 - 25,000/mm3; <50.0 - 25.0 x 10e9 /L <25,000/mm3; <25.0 x 10e9 /L - A finding based on laboratory test results that indicate a decrease in number of platelets in a blood specimen.
34 LB AMYLASE 10040139 Investigations Serum amylase increased Yes >ULN - 1.5 x ULN >1.5 - 2.0 x ULN; >2.0 - 5.0 x ULN and asymptomatic >2.0 - 5.0 x ULN with signs or symptoms; >5.0 x ULN and asymptomatic >5.0 x ULN and with signs or symptoms - A finding based on laboratory test results that indicate an increase in the levels of amylase in a serum specimen. Clarification: Grade 2, 3, 4
35 LB TSH 10043770 Investigations Thyroid stimulating hormone increased Yes TSH increased and no intervention initiated - - - - A disorder characterized by an increase in thyroid stimulating hormone. If intervention initiated or symptomatic, report as Endocrine disorders: Hypothyroidism. Addition: Term, Navigational note
36 10059895 Investigations Urine output decreased Yes - - Adult: Oliguria (<80 ml in 8 hr); Infants: < 0.5 mL/kg per hour for 24 hours; Children: < 500 mL/1.73 m2 body surface area per day Adult: Anuria (<240 ml in 24 hr); Pediatric: No urine output over 12 hours - A finding based on test results that indicate urine production is less relative to previous output. Clarification: Grade 3, 4
37 10047580 Investigations Vital capacity abnormal Yes 90 - 75% of predicted value <75 - 50% of predicted value; limiting instrumental ADL <50% of predicted value; limiting self care ADL - - A finding based on pulmonary function test results that indicate an abnormal vital capacity (amount of exhaled after a maximum inhalation) when compared to the predicted value. Also consider Investigations: Forced Expiratory Volume; Respiratory, thoracic and mediastinal disorders: Respiratory failure or Dyspnea Addition: Navigational note
38 VS WEIGHT 10047896 Investigations Weight gain Yes 5 - <10% from baseline 10 - <20% from baseline >=20% from baseline - - A finding characterized by an unexpected or abnormal increase in overall body weight; for pediatrics, greater than the baseline growth curve. Do not use Metabolism and nutrition disorders: Obesity, this term is being retired. Addition: Navigational note; Clarification: Definition
39 VS WEIGHT 10047900 Investigations Weight loss Yes 5 to <10% from baseline; intervention not indicated 10 - <20% from baseline; nutritional support indicated >=20% from baseline; tube feeding or TPN indicated - - A finding characterized by a decrease in overall body weight; for pediatrics, less than the baseline growth curve.
40 LB WBC 10049182 Investigations White blood cell decreased Yes <3000 - 2000/mm3; <3.0 - 2.0 x 10e9 /L <2000 - 1000/mm3; <2.0 - 1.0 x 10e9 /L <1000/mm3; <1.0 x 10e9 /L - A finding based on laboratory test results that indicate an decrease in number of white blood cells in a blood specimen.
41 LB PH 10000486 Metabolism and nutrition disorders Acidosis Yes pH =7.3 - pH <7.3 Life-threatening consequences Death A disorder characterized by abnormally high acidity (high hydrogen-ion concentration) of the blood and other body tissues.
42 LB PH 10001680 Metabolism and nutrition disorders Alkalosis Yes pH >normal, but <=7.5 - pH >7.5 Life-threatening consequences Death A disorder characterized by abnormally high alkalinity (low hydrogen-ion concentration) of the blood and other body tissues.
43 LB CA 10020587 Metabolism and nutrition disorders Hypercalcemia Yes Corrected serum calcium of >ULN - 11.5 mg/dL; >ULN - 2.9 mmol/L; Ionized calcium >ULN - 1.5 mmol/L Corrected serum calcium of >11.5 - 12.5 mg/dL; >2.9 - 3.1 mmol/L; Ionized calcium >1.5 - 1.6 mmol/L; symptomatic Corrected serum calcium of >12.5 - 13.5 mg/dL; >3.1 - 3.4 mmol/L; Ionized calcium >1.6 - 1.8 mmol/L; hospitalization indicated Corrected serum calcium of >13.5 mg/dL; >3.4 mmol/L; Ionized calcium >1.8 mmol/L; life-threatening consequences Death A disorder characterized by laboratory test results that indicate an elevation in the concentration of calcium (corrected for albumin) in blood.
44 LB K 10020647 Metabolism and nutrition disorders Hyperkalemia Yes >ULN - 5.5 mmol/L >5.5 - 6.0 mmol/L; intervention initiated >6.0 - 7.0 mmol/L; hospitalization indicated >7.0 mmol/L; life-threatening consequences Death A disorder characterized by laboratory test results that indicate an elevation in the concentration of potassium in the blood; associated with kidney failure or sometimes with the use of diuretic drugs. Clarification: Grade 2
45 LB MG 10020670 Metabolism and nutrition disorders Hypermagnesemia Yes >ULN - 3.0 mg/dL; >ULN - 1.23 mmol/L - >3.0 - 8.0 mg/dL; >1.23 - 3.30 mmol/L >8.0 mg/dL; >3.30 mmol/L; life-threatening consequences Death A disorder characterized by laboratory test results that indicate an elevation in the concentration of magnesium in the blood.
46 LB NA 10020680 Metabolism and nutrition disorders Hypernatremia Yes >ULN - 150 mmol/L >150 - 155 mmol/L; intervention initiated >155 - 160 mmol/L; hospitalization indicated >160 mmol/L; life-threatening consequences Death A disorder characterized by laboratory test results that indicate an elevation in the concentration of sodium in the blood. Clarification: Grade 2
47 LB TRIG 10020870 Metabolism and nutrition disorders Hypertriglyceridemia Yes 150 mg/dL - 300 mg/dL; 1.71 mmol/L - 3.42 mmol/L >300 mg/dL - 500 mg/dL; >3.42 mmol/L - 5.7 mmol/L >500 mg/dL - 1000 mg/dL; >5.7 mmol/L - 11.4 mmol/L >1000 mg/dL; >11.4 mmol/L; life-threatening consequences Death A disorder characterized by laboratory test results that indicate an elevation in the concentration of triglyceride concentration in the blood.
48 LB URATE 10020907 Metabolism and nutrition disorders Hyperuricemia Yes >ULN without physiologic consequences - >ULN with physiologic consequences Life-threatening consequences Death A disorder characterized by laboratory test results that indicate an elevation in the concentration of uric acid. Clarification: Grade 1, 3, 4
49 LB ALB 10020943 Metabolism and nutrition disorders Hypoalbuminemia Yes <3 - 2 g/dL; <30 - 20 g/L <2 g/dL; <20 g/L Life-threatening consequences; urgent intervention indicated Death A disorder characterized by laboratory test results that indicate a low concentration of albumin in the blood.
50 LB CA 10020949 Metabolism and nutrition disorders Hypocalcemia Yes Corrected serum calcium of Corrected serum calcium of <8.0 - 7.0 mg/dL; <2.0 - 1.75 mmol/L; Ionized calcium <1.0 - 0.9 mmol/L; symptomatic Corrected serum calcium of <7.0 - 6.0 mg/dL; <1.75 - 1.5 mmol/L; Ionized calcium <0.9 - 0.8 mmol/L; hospitalization indicated Corrected serum calcium of <6.0 mg/dL; <1.5 mmol/L; Ionized calcium <0.8 mmol/L; life-threatening consequences Death A disorder characterized by laboratory test results that indicate a low concentration of calcium (corrected for albumin) in the blood.
51 LB GLUC 10021005 Metabolism and nutrition disorders Hypoglycemia Yes <55 - 40 mg/dL; <3.0 - 2.2 mmol/L <40 - 30 mg/dL; <2.2 - 1.7 mmol/L <30 mg/dL; <1.7 mmol/L; life-threatening consequences; seizures Death A disorder characterized by laboratory test results that indicate a low concentration of glucose in the blood.
52 LB K 10021018 Metabolism and nutrition disorders Hypokalemia Yes Symptomatic with <3.0 - 2.5 mmol/L; hospitalization indicated <2.5 mmol/L; life-threatening consequences Death A disorder characterized by laboratory test results that indicate a low concentration of potassium in the blood. Clarification: Grade 2
53 LB MG 10021028 Metabolism and nutrition disorders Hypomagnesemia Yes <1.2 - 0.9 mg/dL; <0.5 - 0.4 mmol/L <0.9 - 0.7 mg/dL; <0.4 - 0.3 mmol/L <0.7 mg/dL; <0.3 mmol/L; life-threatening consequences Death A disorder characterized by laboratory test results that indicate a low concentration of magnesium in the blood.
54 LB NA 10021038 Metabolism and nutrition disorders Hyponatremia Yes 125-129 mmol/L and asymptomatic 125-129 mmol/L symptomatic; 120-124 mmol/L regardless of symptoms <120 mmol/L; life-threatening consequences Death A disorder characterized by laboratory test results that indicate a low concentration of sodium in the blood. Addition: Grade 2; Clarification: Grade 3
55 10064848 Renal and urinary disorders Chronic kidney disease Yes eGFR (estimated Glomerular Filtration Rate) or CrCl (creatinine clearance) 0.5 eGFR or CrCl 59 - 30 ml/min/1.73 m2 eGFR or CrCl 29 - 15 ml/min/1.73 m2 eGFR or CrCl <15 ml/min/1.73 m2; dialysis or renal transplant indicated Death A disorder characterized by gradual and usually permanent loss of kidney function resulting in renal failure.
56 10037032 Renal and urinary disorders Proteinuria Yes 1+ proteinuria; urinary protein ULN - <1.0 g/24 hrs Adult: 2+ and 3+ proteinuria; urinary protein 1.0 - <3.5 g/24 hrs; Pediatric: Urine P/C (Protein/Creatinine) ratio 0.5 - 1.9 Adult: Urinary protein >=3.5 g/24 hrs; 4+ proteinuria; Pediatric: Urine P/C (Protein/Creatinine) ratio >1.9 - - A disorder characterized by laboratory test results that indicate the presence of excessive protein in the urine. It is predominantly albumin, but also globulin. 24-hour urine collection takes precedence over dipstick Addition: Navigational note; Clarification: Grade 1, 2, 3
57 10030300 Reproductive system and breast disorders Oligospermia Yes Sperm concentration > 0 to < 15 million/ml - - - - A disorder characterized by a decrease in the number of spermatozoa in the semen. Clarification: Grade 1; Deletion: Grade 2, 3
58 10021143 Respiratory, thoracic and mediastinal disorders Hypoxia Yes - Decreased oxygen saturation with exercise (e.g., pulse oximeter <88%); intermittent supplemental oxygen Decreased oxygen saturation at rest (e.g., pulse oximeter <88% or PaO2 <=55 mm Hg) Life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) Death A disorder characterized by a decrease in the level of oxygen in the body.
59 VS 10020772 Vascular disorders Hypertension Yes Adult: Systolic BP 120 - 139 mm Hg or diastolic BP 80 - 89 mm Hg; Pediatric: Systolic/diastolic BP >90th percentile but< 95th percentile; Adolescent: BP 120/80 even if < 95th percentile Adult: Systolic BP 140 - 159 mm Hg or diastolic BP 90 - 99 mm Hg if previously WNL; change in baseline medical intervention indicated; recurrent or persistent (>=24 hrs); symptomatic increase by >20 mm Hg (diastolic) or to >140/90 mm Hg; monotherapy indicated initiated; Pediatric and adolescent: Recurrent or persistent (>=24 hrs) BP >ULN; monotherapy indicated; systolic and /or diastolic BP between the 95th percentile and 5 mmHg above the 99th percentile; Adolescent: Systolic between 130-139 or diastolic between 80-89 even if < 95th percentile Adult: Systolic BP >=160 mm Hg or diastolic BP >=100 mm Hg; medical intervention indicated; more than one drug or more intensive therapy than previously used indicated; Pediatric and adolescent: Systolic and/or diastolic > 5 mmHg above the 99th percentile Adult and Pediatric: Life-threatening consequences (e.g., malignant hypertension, transient or permanent neurologic deficit, hypertensive crisis); urgent intervention indicated Death A disorder characterized by a pathological increase in blood pressure. Clarification: Grade 1, 2, 3, 4, Definition